Wenbo Guo

Ph.D., supervised by Prof. Jin Gu.
MOE Key Laboratory of Bioinformatics
BNRIST Bioinformatics Division
Department of Automation
Tsinghua University

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Research interests

• Single cell data analysis
• Spatial transcriptomics data analysis
• Machine learning
• Probabilistic graphical models

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Publications

• scCancer: a package for automated processing of single cell RNA-seq data in cancer.
  Briefings in Bioinformatics, 2021, 22(3): bbaa127. [Software] [Abstract]
  Wenbo Guo, Dongfang Wang, Shicheng Wang, Yiran Shan, Changyi Liu, Jin Gu#.

• Comprehensive analysis of spatial architecture in primary liver cancer.
  Science Advances, 2021, 7: eabg3750. [Abstract]
  Rui Wu*, Wenbo Guo*, Xinyao Qiu*, Shicheng Wang, Chengjun Sui, Qiuyu Lian, Jianmin Wu, Yiran Shan, Zhao Yang, Shuai Yang, Tong Wu, Kaiting Wang, Yanjing Zhu, Shan Wang, Changyi Liu, Yangqianwen Zhang, Bo Zheng, Zhixuan Li, Yani Zhang, Siyun Shen, Yan Zhao, Wenwen Wang, Jinxia Bao, Ji Hu, Xuan Wu, Xiaoqing Jiang, Hongyang Wang#, Jin Gu#, Lei Chen#.

• Integrative genomic analysis of gemcitabine resistance in pancreatic cancer by patient-derived xenograft models.
  Clinical Cancer Research, 2021, 27(12): 3383-3396. [Abstract]
  Gang Yang*, Wenfang Guan*, Zhe Cao*, Wenbo Guo*, Guangbing Xiong, Fangyu Zhao, Mengyu Feng, Jiangdong Qiu, Yueze Liu, Michael Q Zhang, Lei You#, Taiping Zhang#, Yupei Zhao#, Jin Gu#.

• Elucidating minimal residual disease of pediatric B cell acute lymphoblastic leukemia by single cell analysis.
  Nature Cell Biology, 2022, 24(2): 242-252. [Abstract]
  Yingchi Zhang*, Shicheng Wang*, Jingliao Zhang*, Chao Liu*, Xinqi Li*, Wenbo Guo, Yongjuan Duan, Suyu Zong, Jiarui Zheng, Yixuan Wu, Xiaoli Chen, Xiaoyan Chen, Xuelian Cheng, Yanxia Chang, Yue Wang, Feng Ding, Wenyu Yang, Xiaojuan Chen, Ye Guo, Li Zhang, Yumei Chen, Yao Zou, Xiaofan Zhu#, Jin Gu#, Tao Cheng#.

• JEBIN: analyzing gene co-expressions across multiple datasets by joint network embedding.
  Briefings in Bioinformatics, 2022, 23(2): bbab603. [Abstract]
  Guiying Wu, Xiangyu Li#, Wenbo Guo, Zheng Wei, Tao Hu, Yiran Shan, Jin Gu#.

• Highly regional genes: graph-based gene selection for single cell RNA-seq data.
  Journal of Genetics and Genomics, 2022. [Abstract]
  Yanhong Wu*, Qifan Hu*, Shicheng Wang, Changyi Liu, Yiran Shan, Wenbo Guo, Rui Jiang, Xiaowo Wang, Jin Gu#.

• ClustEx2: gene module identification using density-based network hierarchical clustering.
  Proceedings of 2018 Chinese Automation Congress (CAC), Xi’An, 2018, 2407-2412. [Abstract]
  Zijian Ding, Wenbo Guo, Jin Gu#.